1944's "The Lady and the Monster" was among the few Republic examples of the horror genre (serials and outdoor pictures were their bread and butter), unfortunately tainted by the godawful presence of Czech skating star Vera Hruba Ralston, sweetheart and later bride of studio president Herbert J. Yates, who spent 14 years spending extravagant amounts on her box office failures until the Poverty Row outfit finally collapsed at the same time as RKO. This was the first of three adaptations of the 1942 novel "Donovan's Brain," the first penned by screenwriter Curt Siodmak, so popular that he conceived a 1968 sequel called "Hauser's Memory," earning its lone adaptation as a 1970 TV movie, followed by 1991's "Gabriel's Body." The original title graced the 1953 version with Lew Ayres, while the second remake, 1962's British-German "Vengeance," was branded "The Brain" for American audiences. Yates only decided on the final moniker to signify Vera's importance to this initial screen version (no relation to George Zucco's "The Monster and the Girl"), shooting titles including "The Monster," "The Monster's Castle," "The Monster and the Lady," and "The Brute" (a later reissue earned yet another title, "The Tiger Man"). When cutting away from the intrigue to return to her attractive yet superfluous character the film only grinds to a halt, spending the entire first half on exposition before finally getting down to business. Erich von Stroheim enjoys one of his best remembered leading roles as Dr. Franz Mueller, whose isolated home outside Phoenix is an impressive castle where he conducts experiments on the brains of animals to see how long they survive when the body is deceased. Just as he and assistant Patrick Cory (Richard Arlen) pine for the use of a human specimen a nearby plane crash claims the life of renowned financier William H. Donovan, perhaps the most distinguished brain that any mab lab could want, pronounced dead by the local coroner to allow easier access to what lies inside the skull. Only at the midway point do we finally receive the novel's plot in more detail, Cory (the actual protagonist on the written page) encouraged by Mueller to continue the experiment through a telepathic link, sending the unwitting guinea pig west to Los Angeles to try to free a convicted killer from federal prison. Also taking an interest in Cory's every move are Donovan's scheming attorney (Sidney Blackmer) and faithless wife (Helen Vinson), left penniless by her husband's cleverness, multiple bank accounts set up only by an odd signature. The mystery holds up until the finale, where Cory explains all in a sadly perfunctory dialogue session, Mueller receiving his comeuppance from an unexpected source.