Cisco and Pancho are after a thief who stole $25,000 in bonds from a friend of theirs. They soon begin to suspect that a young woman who is a cook in a hotel is actually the thief's partner.
While in the town of Baxter Center, Cisco and Pancho stop by to drop a letter in the mail. To their surprise, they find themselves being arrested on suspicion of being part of a gang of mail robbers.
After answering Chief Flying Cloud's smoke signal for help in preventing an Indian war, Cisco and Pancho go undercover as Professor Lorenzo Lombardi and Chief Waho's Cure-All Medicine Show, in an attempt to break up an arms smuggling ring.
Cisco and Pancho come to the aid of a lady rancher who's fighting a greedy cattle baron who's making ranchers and drovers pay him for watering their herds.
Cisco and Pancho find themselves being shot at by a quick-tempered young man who's found oil on his ranch and thinks that they're trying to take it from him.
Sally Emerson, believing that Black Lightning, a wild stallion, is stealing her mares, sets out to have him killed, and Cisco and Pancho come to the stallion's rescue to prove its innocence.
In order to break up a gang of vigilantes that's terrorizing the people of Buffalo Flats, Cisco and Pancho head into town disguised as a gambler and an organ grinder.
Cisco and Poncho are trapped by an ex-pirate who runs a slave camp, with Indian guards, in a secret valley with his gorgeous niece who wants no part of it.
While at a gypsy camp, Cisco gets into an altercation over a woman and Pancho finds himself being on the receiving end of the unwelcome attentions of a large dancing bear.
Cisco and Pancho find themselves in the middle of a feud between the guards at a gold mine and the mine's workers, whom the guards suspect of stealing gold from the mine.
Cisco takes part in an endurance race to help prove 4 quarter-horses can beat one thoroughbred, while the man entrusted to hold the race money, is planing to steal it.
Cisco and Pancho get involved when a gang of jewel thieves, who've mailed themselves part of their haul, are prevented from getting their package by a by-the-book postal clerk, and they then decide to take it by force.
Cisco and Pancho find a woman near death in the desert and learn she is a target for murder because she is headed for a ghost town to prove an inheritance and upon accompanying her find an addled innkeeper and other characters.
Cisco tries to save the cabin boy of famed pirate Jean Lafitte--now a wizened old man--from the hands of an ancient old crone and her evil sons, who are after Lafitte's lost treasure.