When Wanda's appendix ruptures with her parents out of town, Doogie ignores hospital policy to operate on her. This creates tension with Dr. Canfield as well as Wanda.
Fed up with being regarded as a 'nerd' by his peers and as a 'little kid' by his co-workers, Doogie decides to throw a party when his parents go away for the weekend.
After arguing with his dad about his finances, Doogie decides to go out on his own and rent an apartment. After hearing that a celebrity is staying at the hospital, Vinnie impersonates Doogie to meet her.
Frustrated with the strict policies, long shifts and stressful atmosphere of Eastman, Doogie gets a lucrative offer from a group of doctors from an upscale Brentwood hospital and seriously considers taking it.
The hospital agrees to let Vinnie film a documentary about Doogie. However, his annoying techniques and intrusive behavior annoy Doogie who must tell a family that their daughter might have cancer.
Doogie's busy schedule causes tension in his relationship with Wanda. He then sees an example of love-gone-wrong at the hospital when one of his patients needs a blood transfusion from his estranged wife who is unwilling to oblige unless he signs the divorce papers.
Doogie fixes Vinnie up with Wanda's cousin who is much larger than everyone expected. At the hospital, Doogie comes across a patient who is obsessed with her appearance.
Doogie's plans to go on a weekend getaway with Wanda are spoiled when he realizes that it's the same weekend as his dad's annual fishing trip. Not wanting to hurt his dad's feelings, he agrees to go.
Doogie and Wanda, feeling pressured to have sex, make plans to sleep together when Doogie's parents go away for the weekend. At the hospital, Doogie treats a 17-year old girl who gives birth and then abandons the baby on his doorstep.
Doogie, upset at the hospital's lack of compassion and adherence to a strict budget, decides to sneak in a dog with a broken leg and operate on it. When he gets caught, his job becomes at risk.